Chronic rhinosinusitis. Chronic sinusitis, unspecified
Conditions
Interventions
Intervention 1: In the intervention group, exosomes derived from mesenchymal stem cells are injected into the polyp and nasal mucosa. The patients are treated for at least 1 month with the standard tr
Sponsors
Kermanshah University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Validation of diagnostic criteria for chronic rhinosinusitis with polyposis Age over 18 years and less than 70 years failure of a previous course of standard treatment informed consent nasal congestion runny nose reduction of smell Obtaining a score of at least 4 out of 8 in the endoscopic scoring criteria based on polyp size (polyps are in the middle saatus and below the lower margin of the middle turbinate)
Exclusion criteria
Exclusion criteria: Suffering from other diseases Uncontrolled high blood pressure Severe coronary artery disease Chronic kidney failure, liver dysfunction, acute respiratory disease and acute infection Nasal septum problems History of smoking and pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Symptoms of allergy. Timepoint: At the beginning of the study, 1 week, 2 weeks and then 1, 2, 3 and 6 months after the end of the study. Method of measurement: Questions from the patient.;Polyp size change. Timepoint: At the beginning of the study, 1 week, 2 weeks and then 1, 2, 3 and 6 months after the end of the study. Method of measurement: Clinical examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Manouchehr Awatef Fazeli
Kermanshah University of Medical Sciences
Outcome results
None listed