Effectiveness of placenta mesenchymal stem cell-derived exosomes on embryo implantation rate in women with recurrent implantation failure

Evaluation of safety and effectiveness of placenta mesenchymal stem cell-derived exosomes on embryo implantation rate in women with recurrent implantation failure: a clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130812014333N223

Enrollment

Registered

2024-08-09

Start date

2024-09-05

Completion date

Unknown

Last updated

2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Recurrent Implantation Failure. Complication associated with artificial fertilization, unspecified

Interventions

The intervention group will receive one exosome unit equal to 2-1.5 x 1010 particles/unit or 200 µg of protein intrauterine and two days before embryo transfer..

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Women with repeated implantation failure (at least two failed embryo transfer cycles) FSH below 10 mIU/mL Normal infectious tests (VDRL, HCV, HBS Ag, HIV)

Exclusion criteria

Exclusion criteria: Thin endometrium Asherman syndrome Chromosomal disorders of couples Spouse's spermogram disorder Immune system diseases including rheumatoid arthritis, autoimmune thyroid, lupus History of cancer, chemotherapy or radiation therapy, use of immunosuppressive drugs including corticosteroids during the last three months History of pregnancy

Design outcomes

Primary

Measure	Time frame
Fever and chills. Timepoint: The end of the study. Method of measurement: Asking the patient.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Kamran Mansouri

Kermanshah University of Medical Sciences

kamranmansouri@gmail.com+98 83 3427 6473

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026