the effect of concomitant use of Lactobacillus Ramnosus probiotic and oral antifungal nystatin on inhibitory intestinal colony growth in Candida albicans in infants under 2500 g

Comparative study of the effect of concomitant use of Lactobacillus Ramnosus probiotic and oral antifungal nystatin on inhibitory intestinal colony growth in Candida albicans in infants under 2500 g

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130812014333N175

Enrollment

100

Registered

2021-09-25

Start date

2021-10-02

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

candida colonization. Neonatal candidiasis

Interventions

Intervention 1: The intervention group will receive 10 drops of nystatin 100,000 oral units 3 times a day along with 10 oral drops of Ramnoflor (Lactobacillus Ramnosus) in the mouth once a day (4 time

Eligibility

Sex/Gender

All

Age

1 Days to 3 Days

Inclusion criteria

Inclusion criteria: Birth weight 2500 grams and less Age of hospitalization time 72 hours and less

Exclusion criteria

Exclusion criteria: Maternal use of oral and topical antifungals during the last month of pregnancy

Design outcomes

Primary

Measure	Time frame
Duration of hospitalization. Timepoint: End of study (10 days after starting the study). Method of measurement: According to documents.;Necrotizing enterocolitis. Timepoint: End of study (10 days after starting the study). Method of measurement: Based on the doctor's diagnosis.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarzad Mashreghi

Kermanshah University of Medical Sciences

farzadmashreghi@gmail.com+98 83 3721 8202

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026