COVID-19. COVID-19
Conditions
Interventions
Intervention 1: The intervention group in addition to the usual treatment will receive single-dose exosomes (one billion exosomes per kilogram) twice on two consecutive days by injection. Regarding th
12000000 unit every other day till 5 dosages, Kaletra, sevodak: daily for 5 days, high dose dexamethasone for 7 days with tapering).
Sponsors
Kermanshah University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Infected patients with Corona virus based on CRISPR test (PCR) Diagnosis of acute respiratory syndrome according to Berlin criteria Requires oxygenation or confirmed pneumonia by radiologically or CT Oxygen uptake concentration Progression of of pulmonary edema more than 50% within 24-48 hours Mild to moderate pneumonia caused by a new coronavirus
Exclusion criteria
Exclusion criteria: Serious underlying illness or psychosis Co-infection with HIV, tuberculosis, influenza virus, adenovirus and other viral respiratory infections Liver or kidney SOFA score more than 3
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygen saturation. Timepoint: 2 to 3 days after injection,daily for two weeks. Method of measurement: Using a pulse oximeter.;Neutrophil to lymphocyte ratio. Timepoint: 2 to 3 days after injection,daily for two weeks. Method of measurement: Using a blood test (To determine the percentage of neutrophils and lymphocytes, the optical method or light microscope and Giemsa staining is used).;Ferritin. Timepoint: 2 to 3 days after injection,daily for two weeks. Method of measurement: Using a blood test and Chemiluminescence immunoassay method. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Kamran Mansouri
Kermanshah University of Medical Sciences
Outcome results
None listed