The effects of stimulation of transcranial direct current in nocturnal sleep on in the mild cognitive impairment patients

Study the effects of stimulation of transcranial direct current in nocturnal sleep on the Glymphatic system in the mild cognitive impairment patients: A randomized controlled parallel clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130812014333N162

Enrollment

Registered

2021-03-17

Start date

2021-04-04

Completion date

Unknown

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild cognitive disorder. Mild cognitive disorder

Interventions

Intervention 1: The first intervention group will receive an active transcranial direct current stimulation (TDCS) overnight. Stimulation begins anodally at a frequency of 0.75 Hz, 4 minutes after ind

Eligibility

Sex/Gender

All

Age

55 Years to No maximum

Inclusion criteria

Inclusion criteria: Age over 55 years Diagnosis of mild cognitive impairment based on Petersen 2004 clinical criteria The score of mental state short test between 24 and 30, and CDR equal to 0.5

Exclusion criteria

Exclusion criteria: History of central nerve diseases (such as stroke, tumor and brain trauma, epilepsy, psychiatric illness, etc.) The presence of metal parts in the brain, skull and anywhere else in the body Alcohol and drug addiction Use of drugs affecting the central nervous system and sleep disorders

Design outcomes

Primary

Measure	Time frame
The rate of activity of the glymphatic system. Timepoint: Before and after interventions (30 minutes after the start of the intervention). Method of measurement: Using Tensor Diffusion Imaging (DTI).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Haj Zeinolabedini

Kermanshah University of Medical Sciences

hanie.zeinolabedini@gmail.com+98 83 3427 4618

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026