Designing and fabricating oral Bioadhesive from Onosma Bulbotricum and study of its therapeutic effect on the patient with Recurrent Aphthous Stomatitis (RAS)

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130812014333N150

Enrollment

120

Registered

2020-05-26

Start date

2020-05-21

Completion date

Unknown

Last updated

2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

recurrent aphthous stomatitis. Recurrent oral aphthae

Interventions

Intervention 1: The intervention group will receive oral Bioadhesive extracted from Onosma Bulbotricum (from borage species) topically for 3 days (several times a day) for a week. Intervention 2: The

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Aphthous stomatitis occurs at least three times a year Age between 18 and 60 years

Exclusion criteria

Exclusion criteria: pregnant women

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: The second day after starting treatment as every other day for one week. Method of measurement: Based on a visual pain scale (VAS).;Number of oral lesions. Timepoint: The second day after starting treatment as every other day for one week. Method of measurement: By a specialist in oral, maxillofacial and facial diseases.;The average diameter of oral lesions. Timepoint: The second day after starting treatment as every other day for one week. Method of measurement: Using a ruler.	—

Measure

Time frame

Pain. Timepoint: The second day after starting treatment as every other day for one week. Method of measurement: Based on a visual pain scale (VAS).;Number of oral lesions. Timepoint: The second day after starting treatment as every other day for one week. Method of measurement: By a specialist in oral, maxillofacial and facial diseases.;The average diameter of oral lesions. Timepoint: The second day after starting treatment as every other day for one week. Method of measurement: Using a ruler.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Reza Tahvilian

Kermanshah University of Medical Sciences

rtahvilian@kums.ac.ir+98 83 3729 6591

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026