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Comparative assessment of the efficacy and safety of addon treatment with “Sofosbuvir-Daclatasvir”, “Lithium”,and “Trifluoprazine” to “standard of care in three groups of patients with COVID-19

Comparative assessment of the efficacy and safety of addon treatment with “Sofosbuvir-Daclatasvir”, “Lithium”,and “Trifluoprazine” to “standard of care in three groups of patients with COVID-19

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20130812014333N147
Enrollment
80
Registered
2020-04-22
Start date
2020-04-08
Completion date
Unknown
Last updated
2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19. COVID-19, virus identified

Interventions

Intervention 1: The first group will receive the standard treatment consisted of 200 mg Tab Hydroxychloroquine 2 times every 12 hours on the first day and then one every 12 hours up to 10 days). Inter

Sponsors

Kermanshah University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age over 18 years Absolute lymphocyte count <1100 / ML or SaO2 <93

Exclusion criteria

Exclusion criteria: Pregnancy or breast-feeding The physician's decision that the trial is not in the patient's interest Any circumstances that do not allow the treatment protocol to be followed easily A history of known allergies to Sofosbuvir-Velp, Trifluoprazine, Lithium and Trihexyphenidyl Drugs that their concomitant use with standard treatment or Sofosbuvir-Velpatasvir, Trifluoprazine, Lithium, and Trihexyphenidyl are contraindicated and can not be discontinued.

Design outcomes

Primary

MeasureTime frame
Not need hospitalization, feels well, and is able to perform normal activities. Timepoint: On days 3, 5 and 10 of treatment. Method of measurement: Based on clinical examination.;Not need hospitalization, feels ill but is able to perform normal activities. Timepoint: On days 3, 5 and 10 of treatment. Method of measurement: Based on clinical examination.;Not need hospitalization, feels ill and isn't able to perform normal activities. Timepoint: On days 3, 5 and 10 of treatment. Method of measurement: Based on clinical examination.;Need hospitalization, feels ill and isn't able to perform normal activities. Timepoint: On days 3, 5 and 10 of treatment. Method of measurement: Based on clinical examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Babak Sayad

Kermanshah University of Medical Sciences

babaksayad@kums.ac.ir+98 83 3427 6306

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026