Comparative study of the effectiveness of fentanyl with and without nitroglycerine spray on hemodynamic response due to laryngoscopy and endotracheal intubation

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130812014333N142

Enrollment

Registered

2020-03-17

Start date

2020-04-07

Completion date

Unknown

Last updated

2020-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

General anesthesia. Cardiac arrest, cause unspecified

Interventions

Intervention 1: The first intervention group will receive fentanyl 2 µg / kg. Intervention 2: The second intervention group will receive two puffs of nitroglycerin spray (400 micrograms) with fentanyl

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age between 20-60 years No history of heart disease or stroke, high blood pressure, and drug use and addiction accidentally

Exclusion criteria

Exclusion criteria: Patients who have had laryngoscopy more than once Patients with diabetes

Design outcomes

Primary

Measure	Time frame
Blood pressure. Timepoint: Before starting the study, before laryngoscopy and intubation and at 10 and 1,3,5,7 minutes, after laryngoscopy and endotracheal intubation. Method of measurement: Using a barometer.;Heart beat. Timepoint: Before starting the study, before laryngoscopy and intubation and at 10 and 1,3,5,7 minutes, after laryngoscopy and endotracheal intubation. Method of measurement: Using the pacemaker.	—

Measure

Time frame

Blood pressure. Timepoint: Before starting the study, before laryngoscopy and intubation and at 10 and 1,3,5,7 minutes, after laryngoscopy and endotracheal intubation. Method of measurement: Using a barometer.;Heart beat. Timepoint: Before starting the study, before laryngoscopy and intubation and at 10 and 1,3,5,7 minutes, after laryngoscopy and endotracheal intubation. Method of measurement: Using the pacemaker.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactJavad Nazari

Kermanshah University of Medical Sciences

sajad.nazari90@yahoo.com+98 83 3427 6306

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026