The effect of COQ10 in combination with levothyroxine for physical and psychotherapy and thyroid hormones levels in Hypothyroid patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130812014333N136

Enrollment

Registered

2020-02-04

Start date

2020-02-14

Completion date

Unknown

Last updated

2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypothyroidism. Other hypothyroidism

Interventions

Intervention 1: In the intervention group, patients received 1.6-1.8 micrograms/kg levothyroxine daily plus 100 mg CoQ10 for 3 months. Intervention 2: In the control group, patients received 1.6-1.8 m

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: overt hypothyroidism based on definition Hypothyroidism controlled by Levothyroxine and T3 level in normal range Hypothyroidism in the age range of 20 to 60 years

Exclusion criteria

Exclusion criteria: Pregnancy taking altering drug metabolism such as weight-loss drugs and antidepressants and hypnotics. Other metabolic and underlying diseases.

Design outcomes

Primary

Measure	Time frame
Sleepiness. Timepoint: At the beginning of the study,, one and a half months later, and at the end of the study, 3 months after the beginning of the study. Method of measurement: Scale Sleepiness Epworth (ESS).;Depression. Timepoint: At the beginning of the study,, one and a half months later, and at the end of the study, 3 months after the beginning of the study. Method of measurement: Beck Depression Inventory.;Fatigue. Timepoint: At the beginning of the study,, one and a half months later, and at the end of the study, 3 months after the beginning of the study. Method of measurement: Fatigue severity scale.;Quality of life. Timepoint: At the beginning of the study,, one and a half months later, and at the end of the study, 3 months after the beginning of the study. Method of measurement: The World Health Organization Quality of Life (WHOQOL).;Symptoms of hypothyroidism. Timepoint: At the beginning of the study,, one and a half months later, and at the end of the study, 3 months after the beginning of the study. Method of measurement: Based on visual pain scale (VAS).	—

Measure

Time frame

Sleepiness. Timepoint: At the beginning of the study,, one and a half months later, and at the end of the study, 3 months after the beginning of the study. Method of measurement: Scale Sleepiness Epworth (ESS).;Depression. Timepoint: At the beginning of the study,, one and a half months later, and at the end of the study, 3 months after the beginning of the study. Method of measurement: Beck Depression Inventory.;Fatigue. Timepoint: At the beginning of the study,, one and a half months later, and at the end of the study, 3 months after the beginning of the study. Method of measurement: Fatigue severity scale.;Quality of life. Timepoint: At the beginning of the study,, one and a half months later, and at the end of the study, 3 months after the beginning of the study. Method of measurement: The World Health Organization Quality of Life (WHOQOL).;Symptoms of hypothyroidism. Timepoint: At the beginning of the study,, one and a half months later, and at the end of the study, 3 months after the beginning of the study. Method of measurement: Based on visual pain scale (VAS).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyedeh Mina Safari

Kermanshah University of Medical Sciences

1364behnasiri@gmail.com+98 83 3427 4618

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026