Comparison of the effect of epinephrine in combination with methylprednisolone on neurological complications in patients with cardiopulmonary arrest

Comparison of the effect of epinephrine in combination with methylprednisolone on neurological complications and the need for vasopressor after resuscitation in patients with cardiopulmonary arrest

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130812014333N127

Enrollment

342

Registered

2019-07-27

Start date

2019-05-15

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiopulmonary arrest. Cardiac arrest

Interventions

Intervention 1: The intervention group, in addition to receiving one mg of epinephrine, in each respiratory resuscitation cycle, every 3 to 5 minutes later will received125 mg intravenous methylpredn

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Above 18 years old No previous neurological disorders Cardiopulmonary arrest

Exclusion criteria

Exclusion criteria: Patients who do not have the possibility of injections during recovery due to the lack of peripheral blood vessels Patients with cardiopulmonary arrest outside the hospital

Design outcomes

Primary

Measure	Time frame
Neurological complications. Timepoint: 24 hours after resuscitation. Method of measurement: Based on a doctor's Checking out and according to Cerebral performance category.;Hypertension. Timepoint: 24 hours after resuscitation. Method of measurement: Using Digital Blood Pressure.;Rhythm during resuscitation. Timepoint: 24 hours after resuscitation. Method of measurement: Using a heart rhythm monitoring device.	—

Measure

Time frame

Neurological complications. Timepoint: 24 hours after resuscitation. Method of measurement: Based on a doctor's Checking out and according to Cerebral performance category.;Hypertension. Timepoint: 24 hours after resuscitation. Method of measurement: Using Digital Blood Pressure.;Rhythm during resuscitation. Timepoint: 24 hours after resuscitation. Method of measurement: Using a heart rhythm monitoring device.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNasrin Bahrami

Kermanshah University of Medical Sciences

Rejimdarmani@yahoo.com+98 83 3427 6330

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026