Comparison of the effect of oral and rectal acetaminophen on the closure of ductus arteriosus in preterm neonates under 35 weeks and 6 days gestational old.

Comparison of the therapeutic and Safety effect of oral and rectal acetaminophen for treatment and safety on the closure of ductus arteriosus in preterm neonates under 35 weeks and 6 days gestational old.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130812014333N118

Enrollment

Registered

2019-04-11

Start date

2019-03-16

Completion date

Unknown

Last updated

2019-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

preterm neonates. Other preterm neonates

Interventions

Intervention 1: In the first intervention group, the treatment will begin with the administration of oral acetaminophen with a dose of 25 mg/kg body weight, then, will be administrated 15 mg per kg b

Eligibility

Sex/Gender

All

Age

3 Days to 14 Days

Inclusion criteria

Inclusion criteria: Preterm neonates under 35 weeks and 6 days gestational old. Age after birth be over 72 hours and less than 14 days Neonates with hemodynamic disorders caused by PDA

Exclusion criteria

Exclusion criteria: Respiratory rate more than 80 per minute Signs of renal failure and oliguria Creatinine clearance less than 10%

Design outcomes

Primary

Measure	Time frame
The closure of ductus arteriosus. Timepoint: The beginning and end of the study. Method of measurement: With echocardiography device.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHashem Gholami

Kermanshah University of Medical Sciences

gholami3280@gmail.com+98 83 3721 8204

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026