Diabetic foot ulcer. Personal history of diabetic foot ulcer
Conditions
Interventions
Intervention 1: Control group: As the control group, the common treatment for the patient is considered. The common treatment for these patients is a combined treatment including surgery, infection co
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Having a diabetic ulcer grade 1 to 4 according to Wagner's classification Having a single wound in the legs and extremities (fingers, soles, heels, on the toes) that has been at least 4 weeks old No smoking, alcohol and drug addiction Not taking drugs that may interfere with wound healing, such as corticosteroids, immunosuppressive agents, and cytotoxic agents Not having concurrent diseases such as cancers, vasculitis, kidney and liver failure, and heart failure that may cause problems in wound healing Informed consent of patients
Exclusion criteria
Exclusion criteria: Patients with acute bone inflammation or osteomyelitis A wound with visible bone in the target area of treatment Infected diabetic foot ulcers Charcot deformity History of treatment with chemotherapy drugs or radiation therapy in 3 months before the start of treatment Hemoglobin less than 10mg/dL History of treatment with growth factors during two weeks before starting treatment Patients with less than 100,000 platelets Vascular problems should not be observed in the wound (not ABI?0.7)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The size of the wound. Timepoint: before dressing and after dressing in the first, second, third, and fourth week after treatment and then in the second, fourth, and sixth months after intervention. Method of measurement: Digital photographic camera, sterile metal ruler.;Wound depth. Timepoint: before dressing and after dressing in the first, second, third, and fourth week after treatment and then in the second, fourth, and sixth months after intervention. Method of measurement: Sterile metal measuring cup. | — |
Secondary
| Measure | Time frame |
|---|---|
| Stress oxidative markers. Timepoint: 6 Months after intervention. Method of measurement: Gene expression level by Real time PCR.;Angiogenesis and inflammation markers. Timepoint: 6 Months after intervention. Method of measurement: Gene expression level by Real time PCR.;MiRNA levels in serum of peripheral blood. Timepoint: 6 Months after intervention. Method of measurement: Gene expression level by Real time PCR. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHamid Reza Rahimi
Mashhad University of Medical Sciences
Outcome results
None listed