triodithyronine (T3) in aluminum phosphide (AlP) poisoning

To determine the cardiovascular effects triodithyronine (T3) in patients poisoned with aluminum phosphide (AlP)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130811014330N8

Enrollment

Registered

2021-02-11

Start date

2018-02-21

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aluminum phosphide poisoning. Toxic effect of pesticides

Interventions

Intervention 1: Intervention group: Drug intervention with standard therapy. Drug intervention: Liothyronine tablet 50 mcg (a single dose) by nasogastric tube, after gastric lavage. Standard therapy:

normal saline serum IV, 10-20 ml/kg

gastric lavage with sodium bicarbonate solution

dopamine IV, 5-15 mcg/kg/min

hydrocortisone IV, 100 mg qid

pantoprazole IV, 40 mg bid

magnesium sulfate IV infusion, 1gr qid

metoclopramide IV, 10 mg qid

calcium gluconate 10% qid. Intervention 2: Control group: Just standard therapy. Standard therapy: oxygen 100%

calcium gluconate 10% qid.

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: aluminum phosphide (AlP) poisoning Informed consent

Exclusion criteria

Exclusion criteria: The patient's silver nitrate test is negative. The patient has taken non-phosphoric rice tablets (herbal type).

Design outcomes

Primary

Measure	Time frame
Mortality rate. Timepoint: Since the entry of the patient in the study until death or discharge from the hospital. Method of measurement: Observation & Investigation.;Cardiovascular & hemodynamic effects. Timepoint: admission time and each 24 hours. Method of measurement: Observation & Investigation.	—

Secondary

Measure	Time frame
Malondealdehyde. Timepoint: Beginning of the study (baseline), 12 to 24 hours after inclusion. Method of measurement: Spectrophotometry.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamid Reza Rahimi

Mashhad University of Medical Sciences

rahimihr@mums.ac.ir+98 51 1800 2288

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026