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Effectiveness of hyaluronic acid for the treatment of interstitial cystitis

Treatment of interstitial cystitis; clinical effectiveness of hydrodistention with intravesical hyaluronic acid (cystistat®) over hydrodistention alone

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20130811014330N5
Enrollment
24
Registered
2018-11-29
Start date
2017-04-21
Completion date
Unknown
Last updated
2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Interstitial cystitis / bladder pain syndrome. Interstitial cystitis (chronic)

Interventions

Intervention 1: Intervention group: Patients were provided with instructions needed before hydrodistention and told not to use a diet that exacerbates interstitial cystitis symptoms. If urinary tract

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Older than 18 years’ old Previously treated with a daily 25 mg of Amitriptyline for at least 1 month, and did not show any improvement in symptoms.

Exclusion criteria

Exclusion criteria: History of bacterial cystitis in the last 3 months History of active genital herpes History of vaginal cervical or uterine cancer History of diverticulum History of cyclophosphamide consumption History of bladder tuberculosis History of abdomen or pelvis radiotherapy Vaginitis symptoms History of bladder stones History of symptom relief with antimicrobials or anticholinergics Frequency of urination less than 8 times a day History of benign or malignant bladder tumors

Design outcomes

Primary

MeasureTime frame
Frequency of urination. Timepoint: Baseline, 1 week, 1 month, and 3 months after intervention. Method of measurement: the O`Leary-Sant questionnaire.;Urgency. Timepoint: Baseline, 1 week, 1 month, and 3 months after intervention. Method of measurement: the O`Leary-Sant questionnaire.;Nocturia. Timepoint: Baseline, 1 week, 1 month, and 3 months after intervention. Method of measurement: the O`Leary-Sant questionnaire.;Dysuria. Timepoint: Baseline, 1 week, 1 month, and 3 months after intervention. Method of measurement: the O`Leary-Sant questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamidreza Rahimi

Mashhad University of Medical Sciences

rahimihr@mums.ac.ir+98 51 3800 2301

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026