diabetic foot ulcer.
Conditions
Interventions
Intervention 1: Control group: The patients in the control group are treated with routine dressing. The common treatment for these patients is a combined treatment including surgery, infection control
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Having a diabetic ulcer grade 1 to 4 according to Wagner's classification Having a single wound in the legs and extremities (fingers, soles, heels, on the toes) that has been at least 4 weeks old No smoking, alcohol and drug addiction Not receiving biological drugs Not having concurrent diseases such as cancers, vasculitis, kidney and liver failure, and heart failure that may cause problems in wound healing Vascular problems should not be observed in the wound (ankle-Brachial Index (ABI) should not be less than 0.7)
Exclusion criteria
Exclusion criteria: patients with history of osteomyelitis Presence of exposed bone within the wound area patient with infected diabetic foot ulcer Concurrent participation in other clinical trials Hemoglobin less than 10mg/dL
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The size of the wound. Timepoint: before traetment and days of 7, 14, 21, 28 and 3 months after traetment. Method of measurement: Digital camera. | — |
Secondary
| Measure | Time frame |
|---|---|
| Expression of inflammatory gene IL-6. Timepoint: before the intervention and 3 months after the completion of intervention. Method of measurement: Gene expression level by Real time PCR by TaqMan probe.;Expression of inflammatory gene IL-1. Timepoint: before the intervention and 3 months after the completion of intervention. Method of measurement: Gene expression level by Real time PCR by TaqMan probe. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHamid Reza Rahimi
Mashhad University of Medical Sciences
Outcome results
None listed