The effects of adding letrozole to methotrexate on the management of tubal ectopic pregnancies

The effects of adding letrozole to methotrexate on the management of tubal ectopic pregnancies at Yas Hospital

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130808014301N2

Enrollment

Registered

2020-07-01

Start date

2020-07-22

Completion date

Unknown

Last updated

2020-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tubal ectopic pregnancy. Tubal pregnancy

Interventions

Intervention 1: Intervention group: The main treatment is a single dose of 50 mg/m2 intramuscular methotrexate injection. By the day of methotrexate injection, the interventional treatment as Abureyha

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Tubal ectopic pregnancies BetaHCG level less than 5000 IU/L

Exclusion criteria

Exclusion criteria: Fetal heart rate Hemodynamic instability Significant abdominal pain History of allergic reactions to methotrexate History of allergic reactions to letrozole and other aromatase inhibitor agents hypercholesterolemia Liver enzymes abnormalities Abnormal renal function tests Heterotopic pregnancies

Design outcomes

Primary

Measure	Time frame
Blood beta-HCG level changes. Timepoint: Before, and 4 and 7 days after beginning of the treatment, then weakly until the negative test. Method of measurement: blood test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Zahra Khalaj Sereshki

Tehran University of Medical Sciences

zahrakhalaj@yahoo.com+98 21 8890 0002

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026