Comparison of prophylactic administration of cefazolin, ampicillin and azithromycin in prevention of postpartum infections after cesarean

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013080710511N2

Enrollment

375

Registered

2013-08-21

Start date

2012-10-11

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postpartum infection. Complications predominantly related to the puerperium

Interventions

Intervention 1: receiving routine prophylactic (cefazolin 2 g of 30 to 60 minutes before cutting). Intervention 2: regimen of 2 g of cefazolin in 30 to 60 minutes before cutting + 500 mg intravenous a

Prevention

receiving routine prophylactic (cefazolin 2 g of 30 to 60 minutes before cutting)

regimen of 2 g of cefazolin in 30 to 60 minutes before cutting + 500 mg intravenous azithromycin

regimen of ampicillin 2 g in 30 to 60 minutes before cutting + 500 mg intravenous azithromycin

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria were: Non-elective Caesarean section women candidates; Gestational age of 28 weeks and more. Exclusion criteria were: Sensitivity to cefazolin or ampicillin or azithromycin; Unwillingness of patients; Received systemic antibiotics within 2 last weeks; Fever prior cesarean; PROM more than 18 hours; chorioamnionitis; Receiving immunosuppressive drugs; Diseases such as diabetes and immune deficiency: liver disease, kidney disease and heart failure or pulmonary edema; multiple pregnancies; preeclampsia; Urinary tract infection or pneumonia; Operation for more than an hour; Intraoperative subcutaneous drains; Abnormal adherence of the placenta to be observed during operation; Elective caesarean; Diarrhea at the time of delivery; Any patient with significant electrolyte disturbances such as hypokalemia, hypocalcemia.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Postpartum infection. Timepoint: Discharge, 2 weeks and 6 weeks after surgery. Method of measurement: Fever, abdominal pain, uterine tenderness, erythema, and purulent discharge from the wound.	—

Secondary

Measure	Time frame
Duration of hospitalization. Timepoint: Study duration. Method of measurement: Medical record.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Maryam Karamali

Arak University of Medical Sciences

dr.karamali@arakmu.ac.ir; drkaramali88@yahoo.com+98 86 1278 0660

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026