Effects of 0.5% captopril cream with 2% diltiazem cream on chronic anal fissure

Comparison the effects of 0.5% captopril cream with 2% diltiazem cream on chronic anal fissure

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201308043014N7

Enrollment

Registered

2014-10-12

Start date

2014-03-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anal fissure. Chronic anal fissure

Interventions

Intervention 1: Captopril 2% cream ,BID FOR 2 Weeks for 1 cm. Intervention 2: intervention 1 : Cream 0.5 % captopril BID for 2weeks.each dose 1 cm. Intervention 3: intervention 2 : Diltiazem 2 % cream

Treatment - Drugs

Captopril 2% cream ,BID FOR 2 Weeks for 1 cm

intervention 1 : Cream 0.5 % captopril BID for 2weeks.each dose 1 cm

intervention 2 : Diltiazem 2 % cream BID for 2 weeks each dose 1 cm

Eligibility

Sex/Gender

All

Age

15 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients who had anal fissure ? between 18-65 years old exclusion criteria :Individuals who show hypersensivity to the product ? the patients with hypertension using ACEI ? and those with increased ulcer size after using the product

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: Each weeks for 2 weeks then each month for 2 month. Method of measurement: Visual analog.	—

Secondary

Measure	Time frame
Iitching. Timepoint: Each month till 2 month. Method of measurement: 5D.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRoja Qobadi Ghadikolaei

Mazandaran University of Medical Sciences, Vice chancellor for research

roja.ghobadi@gmail.com+98 15 1311 0267

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026