Comparison of the efficacy of citalopram and compound of Asperugo procumbens and foeniculum vulgare in treatment of menopausal disorders

Comparative efficacy of citalopram and compound of Asperugo procumbens and foeniculum vulgare in treatment of sleep disorders in menopausal women in Vali-e-Asr Hospital and women’s general hospital (Mirza Koochak Khan) in 1391-1392

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013072714174N1

Enrollment

Registered

2014-01-08

Start date

2013-08-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Menopausal and female climacteric states. Symptoms such as flushing, sleeplessness, headache, lack of concentration, associated with menopause

Interventions

Intervention 1: Citalopram Tablet 40 mg oral (start with 20mg and increase to 40mg after one week), daily for 8 weeks. Intervention 2: Compound of Asperugo Procumbens and Foeniculum Vulgare, Tablet 60

Treatment - Drugs

Citalopram Tablet 40 mg oral (start with 20mg and increase to 40mg after one week), daily for 8 weeks

Compound of Asperugo Procumbens and Foeniculum Vulgare, Tablet 600mg, oral, daily for 8 weeks

Placebo, Tablet, oral, daily for 8 weeks

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Major exclusion criteria include drug consumption (eg. antidepressants, benzodiazepines); having psychological disorders such as depression; history of any medical disease such as thyroid disorders; cardiac disease; dyslipidemia; hypertension; diabetes; estrogen-dependent malignancies. Major inclusion criteria include cessation of monthly periods; confirming lab tests for menopause; having complaint of sleep disorders; negative pregnancy test; and normal lab tests including lipoprotein profile, blood sugar, thyroid and CBC in the last year.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Postmenopausal sleep disorders. Timepoint: Before intervention, one month after intervention, two months after intervention. Method of measurement: Pitssburgh questionnaire.	—

Secondary

Measure	Time frame
Depression. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: Standard Beck questionnaire.;Nausea. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: History.;Flushing. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: History.;Vomitting. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: History.;Headache. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: History.;Constipation. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: History.;Drowsiness. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: History.;Vaginal dryness. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: History.;Sexual disorders. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: History.;Vaginal atrophy. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: Physical Examination.;Vaginal itching. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: History.;Breast pain. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: History.;Skin changes. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: History.	—

Measure

Time frame

Depression. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: Standard Beck questionnaire.;Nausea. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: History.;Flushing. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: History.;Vomitting. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: History.;Headache. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: History.;Constipation. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: History.;Drowsiness. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: History.;Vaginal dryness. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: History.;Sexual disorders. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: History.;Vaginal atrophy. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: Physical Examination.;Vaginal itching. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: History.;Breast pain. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: History.;Skin changes. Timepoint: before intervention, one month after intervention, two months after intervention. Method of measurement: History.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohamad Naser Jalalian

Tehran University of Medical Sciences

hpl_n_jalalian@yahoo.com+98 21 8869 8556

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 16, 2026