End stage kidney disease on hemodialysis. End stage kidney disease
Conditions
Interventions
Intervention 1: The intervention group consisted of 18 patients that they will receive oral probiotic supplement capsule, 500 mg per day for 12 weeks, after a meal. Intervention 2: The control grou
Treatment - Drugs
The intervention group consisted of 18 patients that they will receive oral probiotic supplement capsule, 500 mg per day for 12 weeks, after a meal.
The control group consisted of 18 patients that they will receive oral Placebo capsules, one number per day for 12 weeks, after a meal.
Sponsors
Deputy of Research andTechnology, Golestan University
Eligibility
Sex/Gender
All
Age
17 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Over 17 years old; Both sexess; Erythropoietin therapy for at least 4 weeks; Hemodialysis treatment for at least 6 months; 3 times dialysis per week and 4 hours per session; Hemoglobin concentration <11g/dL in at least 3 episode; CRP more than 10 mg/ lit; No sever hyperparathyroidism; No surgery or bleeding in the last 3 months; Lack of Hemoglobin disorder including: Thalassemia or Sickle cell anemia; Lack of iron deficiency; Lack of folate and vitamin B12 deficiency; Absence of active infection; Lack of immune disorders such as Lupus erythematosus; Absence of malignancy; No Alcohol consuming; No Consumption antibiotics in 10 days ago; No Consumption corticosteroids; Lack of viral infections: AIDS; No Hospitalization; Exclusion criteria: Antibiotic therapy during the study; Hospitalization; Blood transfusion during the study; Surgery during the study; Change in drug program that it is effective on the anemia; Change in dialysis program; No Patient's tendency to stay in study; Malignancy diagnosis during the study; The presence of bleeding disorders during the study;
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemoglobin measurement. Timepoint: Before the intervention and three episode after intervantion With each month interval. Method of measurement: Laboratory equipment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quantitative CRP. Timepoint: Before the intervention and three episode after intervantion With each month interval. Method of measurement: Laboratory equipment.;Blood presure. Timepoint: Three months before and three months after the intervention. Method of measurement: manometer.;Defecation pattern. Timepoint: Before the intervention and after the intervention three times with an interval of one month. Method of measurement: Bristol scale and patient statement. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactzahra shariaty
Golestan University of Medical Sciences
Outcome results
None listed