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Effect of vitamin A on pyelonephritis

Effects of oral vitamin A supplementation in girls with acute pyelonephritis

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20130726014170N3
Enrollment
106
Registered
2018-07-22
Start date
2015-03-01
Completion date
Unknown
Last updated
2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Urinary tract infection. Urinary tract infection, site not specified

Interventions

Intervention 1: Intervention group: Oral vitamin A capsules (1,500 U/kg/day
a maximum of 50,000 U) were administered for 10 days (during the acute phase of infection). The vitamin A were provided by Jaber Ibn Hayyan pharmaceutical company,Tehran, Iran. Intervention 2: Contro

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
2 Years to 12 Years

Inclusion criteria

Inclusion criteria: Positive urine culture for Escherichia coli Positive clinical manifestations of urinary tract infection Fever Renal scan indicating acute pyelonephritis

Exclusion criteria

Exclusion criteria: History of recurrent urinary tract infection Renal scarring on the baseline scan Frequent vomiting Severe dehydration Sepsis Systemic hypertension Neurogenic bladder Obstructive uropathy Low baseline serum levels of vitamin A Vesicoureteral Reflux grade >III Urinary calculi Voiding dysfunctions Any unilateral or bilateral renals anatomical anomaly

Design outcomes

Primary

MeasureTime frame
The condition of the clinical symptoms of urinary tract infection. Timepoint: One time before the treatment begins and daily up to 10 days after starting treatment. Method of measurement: clinical symptoms of urinary tract infection checklist.

Secondary

MeasureTime frame
The persistence of the photopenic lesions with or without volume loss. Timepoint: At the beginning of the study (before the intervention) and 6 months later. Method of measurement: 99mTc-dimercaptosuccinic acid (DMSA) renal cortical scan.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactManijeh Kahbazi

Arak University of Medical Sciences

m_kahbazi77@yahoo.com+98 86 3313 3193

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026