obsessive-compulsive disorder. Obsessive-compulsive disorder
Conditions
Interventions
Intervention 1: Intervention group: Continued treatment with serotonin reuptake inhibitor along with oral ondansetron tablet 2 mg in twice daily (4 mg daily) for 18 weeks. Ondansetron was provided by
Sponsors
Arak University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Diagnosis of OCD established by clinical interview (using The Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV) Axis I Disorders) Resistant or inadequacy of Serotonin reuptake inhibitor (SRIs) treatment response
Exclusion criteria
Exclusion criteria: Diagnosis of schizophrenia, schizoaffective disorder, organic mental disorder, bipolar disorder, substance dependence or abuse, and other comorbid DSM-IV Axis I disorders History of seizure, suicidal ideation? and significant head trauma Recent receiving antipsychotics in the treatment of obsessive-compulsive disorder Intelligence quotient less than 70 history of treatment resistance pregnancy and/or lactation Having significant cardiovascular, hepatic, renal or pulmonary diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes from baseline Yale-Brown Obsessive Compulsive Scale (YBOCS) total, Obsession and Compulsion subscale score. Timepoint: Every two weeks for 18 weeks. Method of measurement: Yale-Brown Obsessive Compulsive Scale (YBOCS). | — |
Secondary
| Measure | Time frame |
|---|---|
| Partial treatment response. Timepoint: Every two weeks for 18 weeks. Method of measurement: Yale-Brown Obsessive Compulsive Scale (YBOCS). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMojtaba Sharafkhah
Arak University of Medical Sciences
Outcome results
None listed