Effect of ANGIPARS drug on treatment of gum disease.

Comparison of ANGIPARS and placebo on enhancement of nonsurgical periodontal treatment outcome in moderate to severe periodontitis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201307248898N2

Enrollment

Registered

2014-07-12

Start date

2013-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Periodontitis. Chronic Periodontitis

Interventions

Intervention 1: Semelil, oral 100mg capsules, twice daily for 3 months. Intervention 2: Placebo in the form of oral capsules, twice daily for 3 months.

Treatment - Drugs

Placebo

Semelil, oral 100mg capsules, twice daily for 3 months

Placebo in the form of oral capsules, twice daily for 3 months

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion Criteria: moderate to severe generalized chronic periodontitis patients Exclusion Criteria: moderate to severe generalized chronic periodontitis patients with history of systemic disorders ( DM, Cancer, Immune system disorders, bone metabolic disorders, diseases affecting healing potential, radiotherapy history, immunosuppressive treatments); Smoking; Pregnancy or lactation; Taking systemic antibiotics within 2 months; Taking long-term NSAIDs; Periodontal treatments within 1 year

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Plaque Index. Timepoint: Before intervention and 3 months after invertion. Method of measurement: Visual evaluation and periodontal probe.;Modified Gingival Index. Timepoint: before intervention and 3 months after invertion. Method of measurement: Visual evaluation.;Modified Sulcular Bleeding Index. Timepoint: before intervention and 3 months after invertion. Method of measurement: Periodontal probe.;Probing Depth. Timepoint: before intervention and 3 months after invertion. Method of measurement: Periodontal probe.;Clinical Attachment Level. Timepoint: before intervention and 3 months after invertion. Method of measurement: periodontal probe.;8-hydroxy2-deoxyguanosine level. Timepoint: before intervention and 3 months after invertion. Method of measurement: colorimetric measurement in 450 nm with ELIZA kit.;IL-1ß level. Timepoint: before intervention and 3 months after intervention. Method of measurement: optical density measurement in 450 nm with ELIZA kit.;Lipid peroxidation level. Timepoint: before intervention and 3 months after intervention. Method of measurement: optical density measurement of TBARS in 530-535 nm with ELIZA kit.	—

Measure

Time frame

Plaque Index. Timepoint: Before intervention and 3 months after invertion. Method of measurement: Visual evaluation and periodontal probe.;Modified Gingival Index. Timepoint: before intervention and 3 months after invertion. Method of measurement: Visual evaluation.;Modified Sulcular Bleeding Index. Timepoint: before intervention and 3 months after invertion. Method of measurement: Periodontal probe.;Probing Depth. Timepoint: before intervention and 3 months after invertion. Method of measurement: Periodontal probe.;Clinical Attachment Level. Timepoint: before intervention and 3 months after invertion. Method of measurement: periodontal probe.;8-hydroxy2-deoxyguanosine level. Timepoint: before intervention and 3 months after invertion. Method of measurement: colorimetric measurement in 450 nm with ELIZA kit.;IL-1ß level. Timepoint: before intervention and 3 months after intervention. Method of measurement: optical density measurement in 450 nm with ELIZA kit.;Lipid peroxidation level. Timepoint: before intervention and 3 months after intervention. Method of measurement: optical density measurement of TBARS in 530-535 nm with ELIZA kit.

—

Secondary

Measure	Time frame
White lesions in oral mucosa. Timepoint: after intervention every 4 weeks. Method of measurement: Visual evaluation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mojgan Paknejad

Dental School of Tehran University of Medical Sciences

mpaknejad@sina.tums.ac.ir+98 21 8835 1170

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026