Traumatic brain injury. Diffuse brain injury , Focal brain injury
Conditions
Interventions
Intervention 1: In the intervention group: After the arrival of the patient into the study and within 8 hours after the occurrence of the brain Injury, erythropoietin will be infused at the rate of 33
Treatment - Drugs
In the intervention group: After the arrival of the patient into the study and within 8 hours after the occurrence of the brain Injury, erythropoietin will be infused at the rate of 33000 IU/50 ml nor
In the control group: After the arrival of the patient into the study and within 8 hours after the occurrence of the brain Injury, normal saline will be infused at the rate 50 ml in 30 minutes intrave
Sponsors
Kashan University of Medical Sciences, Deputy of Research
Eligibility
Sex/Gender
All
Age
15 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: severe brain injury (Glasgow coma scale less than or equal to 8) with a single brain lesion volume less than 30 ml or those who have diffuse axonal injury; age between 15-65 years; no need for surgical operation; possibility of following up during the study period; having informed consent from first-degree relatives. Exclusion criteria: mild to moderate brain injury; patients with massive brain lesions( more than 30 ml volume); age less than 15 and over 65; surgical operation; cases with neoplasia in skull; multiple trauma; myeloproliferative diseases; polycythemia; sensitivity to erythropoietin; hyperkalemia; creatinine more than 3 mg/dl; all patients that their following- up is not guaranteed during the study; participating other trials; history of deep vein thrombosis; pregnancy; clinical brain death (without brain stem reflexes).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient's outcome. Timepoint: 3 and 6 month after intervention. Method of measurement: Based on Glasgow coma scale.;Lesion size. Timepoint: Before, 15 and 30 days after intervention. Method of measurement: Based on CT-Scan and radiologist's report. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehrdad Mahdian
Kashan University of Medical Sciences
Outcome results
None listed