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Combination of trauma and drug as a treatment for implantation failure

The effect of endometrial local injury and GnRH agonist on pregnancy rate in patients with recurrent implantation failure

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2013072412146N2
Enrollment
76
Registered
2013-08-03
Start date
2013-01-10
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female infertility. Female infertility

Interventions

Intervention 1: For intervention group: A pipelle biopsy to cause endometrial trauma in the day 19th will be performed and superfact 500µg subcutaneously in the day 21st of the menstrual period will b
Treatment - Other
Treatment - Drugs
For intervention group: A pipelle biopsy to cause endometrial trauma in the day 19th will be performed and superfact 500µg subcutaneously in the day 21st of the menstrual period will be administered a
For control group superfact 500µg subcutaneously will be administered in day 21st of the menstrual period and then routine in vitro fertilization will be performed.

Sponsors

Vice chancellor for research, Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients with two or more implantation failure in IVF; to be 18 to 40 years old; not to suffer from any systemic disease such as diabetes, hypertension, etc.) Exclusion criterion: occurrence of intolerable adverse effects.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Pregnancy. Timepoint: 10 days after in vitro fertilization. Method of measurement: Sending blood sample to laboratory to measure Beta HCG level.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactArefe Fakour

Tabriz University of Medical Sciences

a.Fakour@yahoo.com+98 41 1335 7310

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026