Total Parenteral Nutrition. Endocrine, nutritional and metabolic diseases
Conditions
Interventions
Intervention 1: Intervention 1: A 24-hour infusion of regular insulin in dextrose solution
regular insulin dose is proportional to receiving dextrose and blood glucose level. Intervention 2: Intervention 2: Insulin glargine once daily by subcutaneous injection
insulin glargine dose is proportional to receiving dextrose and blood glucose level.
Treatment - Drugs
Intervention 1: A 24-hour infusion of regular insulin in dextrose solution
regular insulin dose is proportional to receiving dextrose and blood glucose level.
Intervention 2: Insulin glargine once daily by subcutaneous injection
Sponsors
Deputy of Research, Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: with the consent of the patient or the qualified relatives; aged over 18 years; patients who are NPO for at least 7 days or more candidates for receiving PN. Exclusion criteria: autoimmune diseases, HIV infection and sepsis; diabetes mellitus; pregnancy; on dialysis or GFR < 10 mL/min (due to the pharmacokinetics of insulin); any hypersensitivity to PN components or insulin glargine; receiving corticosteroids, catecholamines, or getting PO.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glycemic control. Timepoint: At baseline then four times a day untill the end of the study. Method of measurement: Blood glucose test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum electrolytes. Timepoint: At baseline then daily. Method of measurement: Measurement of electrolytes. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Bagher Oghazian
Tehran University of Medical Sciences
Outcome results
None listed