Diabtes type 2. Non-insulin dependent diabetes mellitus
Conditions
Interventions
Intervention 1: Intervention group: Received 500mg Nigella sativa oil two times a day orally for two months. Intervention 2: Placebo group: Received 500mg mineral oil orally two times a day for two mo
Treatment - Drugs
Intervention group: Received 500mg Nigella sativa oil two times a day orally for two months
Placebo group: Received 500mg mineral oil orally two times a day for two months
Sponsors
Vice Chancellor for research of Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: subjects between 18-60 years old; type 2 diabetic patients without insulin therapy; patients with history of diabetes more than one year; patients with body mass index between 18 to 35 kg/m2. Exclusion criteria: pregnant or lactating women; smokers and alcohol consumers; patients consume antioxidant supplements (vitamin E and C, caroteniodes and coQ10); patients with cardiac, hepatic, respiratory and chronic renal diseases; patients with acute or chronic inflammation
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fasting blood glucose. Timepoint: Baseline and after 8 weeks of intervention. Method of measurement: Enzymatic colorimetric.;Fasting insulin serum. Timepoint: Baseline and after 8 weeks of intervention. Method of measurement: ELISA assay.;HbA1C (Glycosilated hemoglobin). Timepoint: Baseline and after 8 weeks of intervention. Method of measurement: ELISA.;Insulin resistance. Timepoint: Baseline and after 8 weeks of intervention. Method of measurement: HOMA-IR calculation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Lipid profiles (TC, TG, LDL-C, HDL-C). Timepoint: Baseline and after 8 weeks of intervention. Method of measurement: Enzymatic methods for TC,TG and HDL-C For LDL-C : Freidwald’s formula: LDL-C = TC- HDL-C - (TG/5).;TNF-a. Timepoint: Baseline and after 8 weeks of intervention. Method of measurement: ELISA.;IL-1ß. Timepoint: Baseline and after 8 weeks of intervention. Method of measurement: ELISA.;Anthropometric index(weight and Body Mass Index). Timepoint: before and after 8 weeks intervention. Method of measurement: Analogue scale for weight and weight(Kg)/Square Height for body mass index.;Serum malondialdehyde(MDA). Timepoint: Baseline and after 8 weeks of intervention. Method of measurement: spectrophotometry.;Nitret oxid(NO). Timepoint: Baseline and after 8 weeks of intervention. Method of measurement: spectrophotometry.;SOD activity. Timepoint: Baseline and after 8 weeks of intervention. Method of measurement: spectrophotometry.;Catalase enzyme activity. Timepoint: Baseline and after 8 weeks of intervention. Method of measurement: spectrophotometry. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSaeid Hadi
Beheshti University of Medical Sciences
Outcome results
None listed