Recurrent Aphthous Stomatitis. k12.0
Conditions
Interventions
Intervention 1: case group of patients took a daily 500mg tablet of Propolis for 6 months. Intervention 2: control group of patients took one tablet of placebo a day which have same shape as propolis
Treatment - Drugs
case group of patients took a daily 500mg tablet of Propolis for 6 months
control group of patients took one tablet of placebo a day which have same shape as propolis tablet but without the propolis for 6 months.
Sponsors
Oral and Maxillofacial Diseases Research Center of Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1 - confirmed the clinical diagnosis of minor aphthous ulcers. 2 - At least once a month aphthous ulcer recurrence . 3 - a minimum interval of 2 weeks of previous treatment 4 - spontaneous healing wounds less than 2-1 weeks. Exclusion criteria: 1 - Patients with anemia (based on the trial CBC (H1) and the hematologist), blood disorders. 2 - Lack of patient's satisfaction. 3 - Patients who are pregnant, lactating, under 8 years old and disabled. 4–usage of drugs that may affect the immune system. 5- allergy to propolis.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The frequency of recurrent aphthous stomatitis. Timepoint: monthly. Method of measurement: mean number of recurrence during a month. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean size of ulcers. Timepoint: Biweekly. Method of measurement: By caliper.;Pain of ulcers. Timepoint: Biweekly. Method of measurement: VAS system.;Time of healing. Timepoint: Biweekly. Method of measurement: mean number of days of healing of ulcers. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZahra Delavarian
Mashad Faculty of Dentistry
Outcome results
None listed