Condition 1: Pneumonia. Condition 2: GI bleeding. Bacterial pneumonia, not elsewhere classified K92.2 is a billable ICD-10-CM code that can be used to specify a diagnosis.
Conditions
Interventions
Intervention 1: In the Experimental Group: Pantoprazole 40 mg ampoule is administrated intravenously every 12 hours until the patient is infected with pneumonia
the procedure continues for up to 48 hours following extubation. Manufacturing Company: Nycomed, Germany
Brand name: Pantazol. Intervention 2: In the Control Group: Ranitidine 50 mg is administrated intravenously every 8 hours until the patient is infected with pneumonia
the procedure continues for up to 48 hours following extubation. Manufacturing Company: Alborze darou.
Prevention
In the Experimental Group: Pantoprazole 40 mg ampoule is administrated intravenously every 12 hours until the patient is infected with pneumonia
Brand name: Pantazol.
In the Control Group: Ranitidine 50 mg is administrated intravenously every 8 hours until the patient is infected with pneumonia
Sponsors
Vice chancellor for research, Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: 1. 18 Years of age and over 2. Intubation for more than 48 hours 3. No history of pneumonia within 3 months prior to or at the time of admission 4. No history of severe dysphagia 5. No history of deficiency in the immune system 6. No history of gastrointestinal bleeding 7. No history of gastrectomy, erosive gastritis, and reflux 8. No history of lung cancer 9. No transferring of patients from other ICUs. Exclusion Criteria: 1. Renal failure 2. Drug interference 3. Incidence of drug side effects 4. Gastrointestinal bleeding.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ventilator Associated Pneumonia. Timepoint: Daily until the sputum is positively cultured or 48 hours after extubation. Method of measurement: Clinical Pulmonary Infection Score (CPIS)- Sputum Culture. | — |
Secondary
| Measure | Time frame |
|---|---|
| GI bleeding. Timepoint: Daily until the patient remains hospitalized. Method of measurement: Observing the coffee grain contents in the naso- or oro-gastric tube and Melena; checking vital signs such as blood pressure and heart rate, and hemoglobin.;Length of stay in ICU. Timepoint: At the end. Method of measurement: Observation.;Mortality in ICU. Timepoint: At the end. Method of measurement: Observation.;Mortality in ward. Timepoint: At the end. Method of measurement: Observation.;Duration of Mechanical Ventilation. Timepoint: Since the start of mechanical ventilation until the patient is disconnected from the machine. Method of measurement: Observation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHajar Faghihi
Shiraz University Medical Sciences
Outcome results
None listed