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Comparison of muscle relaxation of two medications in breathing intubation of patients

Comparison of muscular relaxation quality between the combination of remifentanil-atracurium and succinylcholine in rapid sequence induction intubation

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT2013071914056N1
Enrollment
70
Registered
2015-07-19
Start date
2013-03-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intubation. Failed or difficult intubation

Interventions

Intervention 1: Intervention group 2: Atracurium, 0.5 mg/kg, intravenously, for muscle relaxation, before anesthesia. Remifentanil, 1 µg/kg, intravenously, before anesthesia. Interve
Intervention group 2: Atracurium, 0.5 mg/kg, intravenously, for muscle relaxation, before anesthesia. Remifentanil, 1 µg/kg, intravenously, before anesthesia.
Intervention group 1: Succinylcholine, 1.5 mg/kg, intravenously, for muscle relaxation, before anesthesia.

Sponsors

Arak University of Medical Sciences, Vice Chancellor for Research
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age between 15-65 years old; Candidate for hernioraphy or elective limb orthopedic surgeriy; ASA class I and II; Body mass index of less than 26; Mallampati score 1 and 2. Exclusion criteria: Mallampati score of 3 or more; patients with neuromuscular diseases; Family history of malignant hyperthermia; Family history of pseudocholinesterase deficiency; Pregnancy; Sensitivity to study medications.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Relaxation of jaw muscles. Timepoint: 50 seconds after the injection of last medication. Method of measurement: Cooper scoring system.;Ease of intubation. Timepoint: 50 seconds after the injection of last medication. Method of measurement: Cooper scoring system.;Ease of laryngoscopy. Timepoint: 50 seconds after the injection of last medication. Method of measurement: Cooper scoring system.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHesameddin Modir

Arak University of Medical Sciences

he_modir@arakmu.ac.ir+98 86 3417 3506

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026