Cognitive disorders in patients with HIV. Mild cognitive impairment, so stated
Conditions
Interventions
Intervention 1: Intervention group: After obtaining informed consent and signing the informed consent form and explaining how to conduct the study, the patients demographic information such as age and
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Adult HIV patients (age between 18 and 65 years old) with cognitive impairment referring to outpatient clinics at Imam Khomeini Hospital Patients have been under antiretroviral treatment for at least 6 months and have a viral load of less than 200 copies per milliliter of blood.
Exclusion criteria
Exclusion criteria: Efavirenz drug use Having an active infection (such as opportunistic infections) Having symptoms of hepatic and renal encephalopathy Using methamphetamines Taking anticholinergic drugs History of coagulation disorder History of taking anticoagulant and antiplatelet drugs History of allergy to rivastigmine drug History of known arrhythmia (such as 2nd and 3rd degree blocks) or sick sinus syndrome History of urinary tract obstruction Acute gastrointestinal ulcer Concomitant use of cholinesterase inhibitor drugs History of epilepsy Pregnant and breastfeeding people Having suicidal thoughts chronic inflammatory diseases such as RA and IBD
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The improvement rate of cognitive impairment. Timepoint: At the beginning and end of the study. Method of measurement: based on the score of CANTAB software. | — |
Secondary
| Measure | Time frame |
|---|---|
| Improving the level of depression, stress and anxiety. Timepoint: The beginning and end of the study. Method of measurement: Based on the DASS21 questionnaire.;Improving the CD4+ cell count. Timepoint: The beginning and end of the study. Method of measurement: based on blood test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactLadan Abbasian
Tehran University of Medical Sciences
Outcome results
None listed