Major Depressive episode. Major Depressive episode
Conditions
Interventions
Intervention 1: Tablet Citalopram 40 mg/day plus Tablet Riluzole 50 mg twice per day as intervention group for 6 weeks. Intervention 2: Tablet Citalopram 40 mg/day plus Tablet placebo as control group
Treatment - Drugs
Placebo
Tablet Citalopram 40 mg/day plus Tablet Riluzole 50 mg twice per day as intervention group for 6 weeks
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria:1. Presence of Major Depressive Disorder based on DSM-IV criteria; Baseline Hamilton Depression Rating Scale (HAM-D) (17-item) score of at least 19. Exclusion criteria: 1. Presence of Psychosis;2.any other diagnosis in Axis I and II; 3.Receiving psychotropic medications;4.receiving any antidepressants during past one month or ECT during past two months;5. Presence of hypothyroidism;6. cardiovascular problems; 7. pregnancy or nursing women; 8.7-rising liver transaminases to three times the upper limit of normal or higher
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of depression. Timepoint: Baseline and weeks 2,4 and 6. Method of measurement: Hamiltion Depression Rating Scale 17-Item. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactProf. Shahin Akhondzadeh
Tehran University of Medical Sciences
Outcome results
None listed