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Comparing the effects of three different additional doses of propofol infusion on intubation condition and hemodynamic changes during general anesthesia under elective surgery

Comparing the effects of three different additional doses of propofol infusion on intubation condition and hemodynamic changes during general anesthesia under elective surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT201307145362N6
Enrollment
140
Registered
2013-08-01
Start date
2011-03-20
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

complications of tracheal intubation. failed or difficult intubation

Interventions

Intervention 1: Group A received additional dose of propofol 0.5 mg/kg infused after an initial dose 1.5 mg/kg .additional dose of propofol was infused within 90 seconds by infusion pump. Intervention
Prevention
Group A received additional dose of propofol 0.5 mg/kg infused after an initial dose 1.5 mg/kg .additional dose of propofol was infused within 90 seconds by infusion pump.
Group B received additional dose of propofol 1mg/kg infused after an initial dose 1mg/kg. additional dose of propofol was infused within 90 seconds by infusion pump.
Group C received additional dose of propofol 1.5 mg/kg after an initial dose 1mg/kg. additional dose of propofol was infused within 90 seconds by infusion pump.
Group D received propofol 2mg/kg as a bolus with no additional dose.

Sponsors

Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: American Society of Anesthesiologists (ASA) physical status | and ? patients ; aged 18 to 60 years ; with normal airway; Body Mass Index less than 27.5 kg/m2 and more than 18.5 kg/m2 . Exclusion criteria : sensitivity to protocol ; anesthesia with techniques, different from the protocol of this study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Intubation conditions. Timepoint: at the time of intubation. Method of measurement: Magorian et al scoring system.;Hemodynamic changes. Timepoint: at preinduction, immediately prior to laryngoscopy, one , three ,five and ten minutes after laryngoscopy. Method of measurement: blood pressure (mmHg) and pulse(bpm) measured by heart monitoring divice.

Secondary

MeasureTime frame
Bronchospasm,laryngospasmand cyanosis. Timepoint: after laryngoscopy and intubation. Method of measurement: observation.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammadreza Safavi,MD

Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences

safavi@med.mui.ac.ir; honarmand@med.mui.ac.ir+98 311625555

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026