Lumbar Disk Herniation. Nerve root and plexus compressions in intervertebral disc disorders
Conditions
Interventions
Intervention 1: Each of participant in case-group will be received one capsule containing cycloserine USP 250mg orally 2 hours before surgery. Intervention 2: In the control group, each patient will
Treatment - Drugs
Placebo
Each of participant in case-group will be received one capsule containing cycloserine USP 250mg orally 2 hours before surgery.
In the control group, each patient will be received a placebo capsule orally 2 hours before surgical intervention. These capsules have similar shape, color, weight of cycloserine ones.
Sponsors
Vice Chancellor for research of Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1. Age: 18-70 years 2. Weight: 60-80kg 3. Informed consent 4. Matched clinical and imaging findings Exclusion criteria: 1. Previous surgery 2. Alcohol or drug addiction 3. Side effects of morphine during study 4. Pregnancy 5. Lactation 6. History of depression 7. History of seizure 8. Multilevel laminectomy or diskectomy 9. Analgesic therapy in the last day 10. Complete postoperative recovery 11. History of diabetes or cardiovascular disease 12. Aphasia or visual loss
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lumbar pain. Timepoint: 2, 6 and 12 hours after surgery. Method of measurement: VAS (visual analog scale). | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensory and motor condition. Timepoint: 2, 6 and 12 hours after surgery. Method of measurement: Frankel classification. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed