Condition 1: Type 2 Diabetes melitus. Condition 2: Atherosclerosis. non-insulin-dependent diabetes Arterial sclerosis
Conditions
Interventions
Intervention 1: Intervention group: DHA supplement (2 gr per day , 3 month). Intervention 2: Control group: Placebo capsule (containing Sunflower oil similar to DHA capsule) with similar dose (2 gr p
Treatment - Drugs
Placebo
Control group: Placebo capsule (containing Sunflower oil similar to DHA capsule) with similar dose (2 gr per day) and similar period (3 month)
Intervention group: DHA supplement (2 gr per day , 3 month)
Sponsors
Tehran University of Medical Sciences
Endocrinology and Metabolism Research Institute
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Type 2 diabetic patients (both males and females); 30-70 years old age; BMI range between 18.5 to 35 kg/m2 Exclusion criteria: Insulin therapy; any type of Cancer; Liver, Kidney, Coagulation and Thyroid disorders; Cardiovascular diseases such as Angina Pectoris, Myocardial infarction, Stroke; consumption of Anticoagulants, ant-inflammatory and lipid lowering agents such as Fibrates; Thiazolidinedione’s therapy; History of Allergic reaction to fish or fish oil; Daily consumption of fish or fish oil supplements; Supplementation with vitamin A,D and B6; Pregnancy and Lactating; lack of usage more than 10% of administered tablets.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Interleukin 6 gene expression. Timepoint: start and end of intervention. Method of measurement: Real time PCR.;TNF-a gene expression. Timepoint: start and end of intervention. Method of measurement: Real time PCR.;ADMA. Timepoint: start and end of intervention. Method of measurement: ELISA.;SCD163. Timepoint: start and end of intervention. Method of measurement: ELISA.;Telomerase activity. Timepoint: start and end of intervention. Method of measurement: PCR-ELISA kit.;Total cholesterol. Timepoint: start and end of intervention. Method of measurement: Turbidimeter.;Triglyceride. Timepoint: start and end of intervention. Method of measurement: Turbidimeter.;HDL- cholesterol. Timepoint: start and end of intervention. Method of measurement: Turbidimeter.;LDL-cholesterol. Timepoint: start and end of intervention. Method of measurement: Friedewald formula.;Fasting Blood Sugar. Timepoint: start and end of intervention. Method of measurement: Turbidimeter.;Fasting insulin. Timepoint: start and end of intervention. Method of measurement: ELISA.;Insulin resistance. Timepoint: start and end of intervention. Method of measurement: Formula.;Glycated hemoglobin. Timepoint: start and end of intervention. Method of measurement: Kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Vascular function and proliferation of smooth muscle cells in intima media. Timepoint: start and end of intervention. Method of measurement: Studding the effective factors in vascular function and proliferation of smooth muscle cells in intima media and also comparison of these factors in two intervention and control groups. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactOmid Toupchian
Tehran University of Medical Sciences
Outcome results
None listed