Ischemic Heart Diseases. Diseases of the circulatory system
Conditions
Interventions
Intervention 1: Intervention 1: Sixty patients who entered in systemic group of this study after anesthetic induction receive 10 mg per kg Tranexamic acid diluted in 20 ml 0.9% Sodium chloride intra v
Treatment - Drugs
Intervention 1: Sixty patients who entered in systemic group of this study after anesthetic induction receive 10 mg per kg Tranexamic acid diluted in 20 ml 0.9% Sodium chloride intra venous during 20
Intervention 2: Sixty patients who entered in local group of this study,receive 1 gr Tranexamic acid diluted in 100 ml Sodium chloride 0.9% in heart pericardium cavity before chest closure and at t
Intervention 3: Sixty patients who entered control group of this study, do not receive any amount of Tranexamic acid or placebo.
Sponsors
Vice chancellor for research, Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Include criteria: all the patients undergoing first coronary artery bypass graft surgery Exclude criteria: Emergency patients; Renal failure patients (creatinine>1.5); Anemic patients (Hemoglobin<11); low Cardiac out put patients (<30%); Coagulopathy disorder patients
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amount of bleeding. Timepoint: 6 hours, 12 hours, 24 hours, 48 hours after surgery. Method of measurement: observing the amount of bleeding in patient chest tubes hourly.;Amount of blood transfusion. Timepoint: During 48 hours after surgery. Method of measurement: noting the amount of blood unite received by patient. | — |
Secondary
| Measure | Time frame |
|---|---|
| Qoagulation and blood factors. Timepoint: Befor surgery, immediately after surgery, 24 hours and 48 hours after surgery. Method of measurement: Labratory tests include: Hb, Hct, Bun, Cr, Pt, Ptt, INR.;Intensive care unit staying days. Timepoint: Daily after surgery. Method of measurement: Questionnaire.;Complications (Emboli, Deep Vein Thrombosis, Seizure, Stroke, Infarction, Reexploration, Death). Timepoint: Daily after surgery. Method of measurement: Questionnaire.;Mechanical ventilation time. Timepoint: Hourly after surgery. Method of measurement: Questionnaire.;Chest closure time. Timepoint: Termination of surgery. Method of measurement: Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Bagher Khosravi
Shiraz University of Medical Sciences
Outcome results
None listed