Bimaxillary Orthognathic Surgery. 00
Conditions
Interventions
Intervention 1: Patients in the first group will be received Magnesium Sulfate an initial dose of 30 mg / kg body weight intravenously during 15 minutes and then continuously magnesium sulfate 10 mg /
Treatment - Drugs
Patients in the first group will be received Magnesium Sulfate an initial dose of 30 mg / kg body weight intravenously during 15 minutes and then continuously magnesium sulfate 10 mg / kg / hr via pum
The placebo group ( Normal saline) will be given an initial dose of the same volume of nomal saline intravenously and infusion of normal saline continued until end of surgery
Sponsors
Vice-Chancellery of Research and Technology, Shiraz University Of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to 40 Years
Inclusion criteria
Inclusion criteria: Patients with no history of systemic disease and without taking any analgesic medications criteria that were willing to cooperate in this study were enrolled; and Exclusion criteria included known allergy to the study drugs; hepatic and renal dysfunction ; patients with heart block or myocardial damage; morbid obesity (BMI = 35); neuromuscular disease; history of neuropathy; asthma; Use of opioid or analgesics 3 days before the study; use of calcium channel blockers and Patients who did not sign the informed consent.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The intensity of the pain. Timepoint: Every half hour for twelve hours after operation. Method of measurement: Visual analog scale.;Heart rate and blood pressure. Timepoint: Before, during and after surgery. Method of measurement: ECG and blood pressure monitoring device.;Duration of surgery. Timepoint: End of surgery. Method of measurement: The Minutes. | — |
Secondary
| Measure | Time frame |
|---|---|
| The use of sedative or narcotic. Timepoint: In the recovery room and surgical ward. Method of measurement: Visual analog scale.;Magnesium Sulfate side effects. Timepoint: Postoperative and in the ward Surgery. Method of measurement: Questionnaire.;Urine volume. Timepoint: From beginning to end the operation. Method of measurement: cc/kg/min. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Asghar Hosseini
Shiraz University Of Medical Sciences
Outcome results
None listed