Major Depressive Disorder. Depressive episode
Conditions
Interventions
Intervention 1: Administration of fluoxetine +placebo. Intervention 2: Administration of fluoxetine+thiamine.
Treatment - Drugs
Administration of fluoxetine +placebo
Administration of fluoxetine+thiamine
Sponsors
Vice chancellor for Research and Technology of Hamadan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: - Diagnosis of major depressive disorder (MDD), according to DSM-V -Age between 18 to 50 years. Exclusion criteria: - Patients with other psychiatric disorders, along with major depression -Debilitating somatic illness, along with major depression -Suffering from Wernicke Syndrome -History of alcohol or substances abuse in the last year -Known gastrointestinal disease -History of long-term dialysis -Suffering from congestive heart failure with long-term use of diuretics -Magnesium deficiency -Suffering from anorexia nervosa -Allergy and sensitivity to thiamine -Thiamine deficiency in laboratory evaluation -Hyperthyroidism
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of symptoms of Depression. Timepoint: Baseline and 3weeks, 6weeks ,12weeks after treatment. Method of measurement: Hamilton Depression Rating Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Hassan Davari
Hamadan University of Medical Sciences
Outcome results
None listed