Using Naproxen-Acetaminophen-Pregabalin as preemptive analgesia in open abdominal surgeries in cancer patients

Three agent preemptive analgesia in laparotomic surgeries for cancer: A Randomized double-blind Clinical Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013070613875N1

Enrollment

Registered

2014-11-09

Start date

2014-11-06

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abdominal cancer. Pelvic cancer, Abdominal Pain. Neoplasm: Abdomen, Neoplasm: Pelvis Groin NOS Sites overlapping systems within the pelvis, such as: rectovaginal (septum) rectovesical (septum),Pain localized to upper abdomen Epigastric pain, Pain localized to other parts of lower abdomen

Interventions

Intervention 1: Intervention group will receive combination of Pregabalin 150 mg, Acetaminophen 1g and Naproxen 250mg (NAG) orally an hour before laparotomy. Intervention 2: Control group will receive

Treatment - Drugs

Placebo

Intervention group will receive combination of Pregabalin 150 mg, Acetaminophen 1g and Naproxen 250mg (NAG) orally an hour before laparotomy

Control group will receive placebo orally an hour before laparotomy

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Laparotomic surgery as a treatment for cancer Exclusion criteria: Taking opiate drugs in the last 48 hours prior to surgery, non elective surgeries, ASA physical status more than 3, patients younger than 18 yo or older than 75 years old, allergy to drugs and opioid, Renal failure, history of peptic ulcer, history of coagulopathy

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Post-surgery pain. Timepoint: hours after surgery: 0, 2, 4, 6, 12, 24, 48. Method of measurement: Universal Pain Assessment Tool.	—

Secondary

Measure	Time frame
Morphin consumption dose. Timepoint: 48 hours afte surgery. Method of measurement: milligram.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarhad Fathi

Tehran Cancer Institute

farhadfathik@gmail.com+98 21 4421 1190

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026