Effect of Vitamin C in Kidney Function After Transplantation

Early Outcome of Kidney Function After Transplantation when Use Vitamin C in Decease Donors.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013070411853N2

Enrollment

180

Registered

2013-09-08

Start date

2013-07-06

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

kidney transplantation. Acute renal failure with tubular necrosis

Interventions

Intervention 1: In this study, we investigated the protective effects of Ascorbic acid(1000 mg I.V. in intervention group) in renal cell damage due to ischemic-re perfusion injury, by measuring NGAL l

Prevention

In this study, we investigated the protective effects of Ascorbic acid(1000 mg I.V. in intervention group) in renal cell damage due to ischemic-re perfusion injury, by measuring NGAL level in brain de

In control group 10cc N/S ( Equivalent with 2 Ampul of Vitamin C) is injected within 6 hours.

Eligibility

Sex/Gender

All

Age

No minimum to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Brain Death Patients in range of 20-65 years old ; Patients with History of kidney problems under Dialysis in list of Transplantation; Patients with kidney problems with Age between 20-60 years Exclusion criteria:Brain Death Patients with history of cardiac problems; Brain Death Patients with Cr>1.5 mg/dl; Brain Death Patients with Age>65 year; Patients with kidney problems with Age>65 years old

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
NGAL (Neutrophil gelatinase- associated lipocalin). Timepoint: baseline values of NGAL is measured in all brain death patients in ICU prior to starting ascorbic acid and then repeat, before aortic clamping in donors and 4 and 24 hours after renal artery declamping in recipients. Method of measurement: By Keith.;BUN. Timepoint: for 5 days post operation. Method of measurement: Lab.;Cr. Timepoint: for 5 days post operation. Method of measurement: Lab.;Frequency of dialysis. Timepoint: for 5 days post operation. Method of measurement: measured in ward.;Total diuretic drugs. Timepoint: for 5 days post operation. Method of measurement: measured in ward.	—

Measure

Time frame

NGAL (Neutrophil gelatinase- associated lipocalin). Timepoint: baseline values of NGAL is measured in all brain death patients in ICU prior to starting ascorbic acid and then repeat, before aortic clamping in donors and 4 and 24 hours after renal artery declamping in recipients. Method of measurement: By Keith.;BUN. Timepoint: for 5 days post operation. Method of measurement: Lab.;Cr. Timepoint: for 5 days post operation. Method of measurement: Lab.;Frequency of dialysis. Timepoint: for 5 days post operation. Method of measurement: measured in ward.;Total diuretic drugs. Timepoint: for 5 days post operation. Method of measurement: measured in ward.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Bagher Khosravi

Shiraz University of Medical Sciences

khosravim@sums.ac.ir+98 71 1233 7636

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026