Is corton beneficial for pediatric patients with coryza undergoing anesthesia?

Respiratory adverse events in children with mild upper respiratory infection: intravenous corticosteroid compared to placebo, randomized blinded clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201307023436N2

Enrollment

200

Registered

2013-07-18

Start date

2013-08-03

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Nasopharyngitis. Coryza (acute)Nasal catarrh, acuteNasopharyngitis

Interventions

Intervention 1: Intervention: Intravenous Hydrocortisone (1mg/kg) and dexamethasone slow iv injection (0.1 mg/kg) , ten minutes before anesthesia. Intervention 2: Control: Intravenous normal sailine w

Prevention

Placebo

Intervention: Intravenous Hydrocortisone (1mg/kg) and dexamethasone slow iv injection (0.1 mg/kg) , ten minutes before anesthesia

Control: Intravenous normal sailine with same volume injected in the intervention group

Eligibility

Sex/Gender

All

Age

1 Years to 6 Years

Inclusion criteria

Inclusion criteria: Inclusion:1- recent (started within two week) upper respiratory infection (URI).2- Mild URI (based on Parnis criteria). 3- anesthesia could not be postponed for 6 weeks later. 4- ASA class II Exclusion: 1- Difficult airway. 2- Cardiac condition. 3- Drug allergy. 4- Change in surgery or anesthesia plan (more drug prescriptions other than protocol) 5- long lasting surgery (more than an hour)

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Cough. Timepoint: (after intervention) Recovery, and 7 days later. Method of measurement: Questionnaire.	—

Secondary

Measure	Time frame
Desaturation (SPO2 less than 92%). Timepoint: (after intervention) Induction, Maintenance, Emergence and Recovery. Method of measurement: Continious pulse oximetry.;Partial Laryngospasm (inspiratory stidor). Timepoint: (after intervention) Induction, maintenance, Emergence and Recovery. Method of measurement: Continious observation.;Bronchospasm (expiratory wheeze). Timepoint: (after intervention) Induction, maintenance, emergence and recovery. Method of measurement: Lung auscultation.;Vomiting. Timepoint: (after intervention) Induction, maintenance, emergence and recovery. Method of measurement: Observation.;Re-admission within a week after discharge (respiratory related). Timepoint: (after intervention) 7 days after anesthesia. Method of measurement: Telephone asking.	—

Measure

Time frame

Desaturation (SPO2 less than 92%). Timepoint: (after intervention) Induction, Maintenance, Emergence and Recovery. Method of measurement: Continious pulse oximetry.;Partial Laryngospasm (inspiratory stidor). Timepoint: (after intervention) Induction, maintenance, Emergence and Recovery. Method of measurement: Continious observation.;Bronchospasm (expiratory wheeze). Timepoint: (after intervention) Induction, maintenance, emergence and recovery. Method of measurement: Lung auscultation.;Vomiting. Timepoint: (after intervention) Induction, maintenance, emergence and recovery. Method of measurement: Observation.;Re-admission within a week after discharge (respiratory related). Timepoint: (after intervention) 7 days after anesthesia. Method of measurement: Telephone asking.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBabak Gharaei

Anesthesiology Research Center, Labbafinejad Hospital, Shahid Beheshti University of Medical Science

babakgharaei@gmail.com+98 21 2360 2175

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026