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comparison of efficacy of indomethacin and magnesium sulphate in prevention of preterm labour

comparison of efficacy of indomethacin and magnesium sulphate in prevention of preterm labour on 28-32 weeks pregnant women referred to Alzahra maternity hospital in Tabriz

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2013062613777N1
Enrollment
150
Registered
2013-10-23
Start date
2013-08-06
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

preterm Labour. Onset (spontaneous) of labour before 37 completed weeks of gestation

Interventions

Case 2: Initially, 50 mg indomethacin , and then 50 mg every 6 hours for 24 hours
Intervention 1: Intervention 1: magnesium sulfate (50%) of 4 mg IV over 20 min, and then 2 mg intravenous infusion every hours until the reduction or cessation of uterine contractions continue. Inter
Treatment - Drugs
Intervention 1: magnesium sulfate (50%) of 4 mg IV over 20 min, and then 2 mg intravenous infusion every hours until the reduction or cessation of uterine contractions continue.

Sponsors

Vice chancellor for research,Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Including criteria: 1- Pregnant women with gestational age of 32-28 weeks 1. Patients who have at least two or more than two contractions lasting 30 seconds during 10 minutes 2. Progress of dilation less than 5-6 cm 3.Effacement of cervix under 50-60% and also be ripe Excluding criteria: 1.Preterm Rupture of amniotic membranes 2.Oligohydramnious 3.Vaginal bleeding 4.nonassuring pattern of fetal heart 5. Allergic responses to indomethacin 6.Renal failure or Gastrointestinal

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Preterm birth. Timepoint: After intervening to fix premature contractions. Method of measurement: Visual pain scale.

Secondary

MeasureTime frame
Neonatal morbidity. Timepoint: After intervening until discharge neonatal from the NICU. Method of measurement: Check list.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Shamsi Abbasalizadeh

Tabriz University of Medical Sciences

abbasalizadehs@tbzmed.ac.ir+98 41 1553 9161

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026