Infertility. Female infertility associated with male factors
Conditions
Interventions
Intervention 1: First group receives GnRH Agonist (Bucerelin, Aventis, Germany) 500 µg subcutaneously from previous midluteal cycle (21th day). Then Estradiol valerat (Daroopakhsh, Iran, 2 mg) daily o
Siemens Medical Solutions, California, USA) is performed every 4 days. After the observation of at least 8mm endometrial thickness, Progesterone (Cyclogest, Germany, 800 mg) is started vaginally. Afte
Treatment - Drugs
First group receives GnRH Agonist (Bucerelin, Aventis, Germany) 500 µg subcutaneously from previous midluteal cycle (21th day). Then Estradiol valerat (Daroopakhsh, Iran, 2 mg) daily oral is started o
Second group, receives letrozole (Iranhormone, Iran, 5mg daily) orally on 2th day of cycle for five days. Then HMG (Ferring, Germany, 75IU daily) is started on 7 day. After the observation of 18mm fol
Sponsors
Vice Chancellor for Research, Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 42 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: Infertile women 18-42 years old with freeze embryo Exclusion Criteria: 1- Male infertility which needs interventions such as TESE (Testicular Sperm Extraction) or PESA (Percutaneous Epididymal Sperm Aspiration) 2- Endometriosis (stage 3 or 4) 3- Uterine myoma with 4cm size or greater 4- Maternal age greater than 42 years old 5- Fresh embryo
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Chemical Pregnancy. Timepoint: 16 days after embryonal transfer. Method of measurement: ßhCG titration. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical pregnancy. Timepoint: 30 days after embryonal transfer. Method of measurement: Observed gestational sac in transvaginal sonography.;Implantation Rate. Timepoint: 30 days after embryonal transfer. Method of measurement: The number of observed gestational sac in transvaginal sonography / the number of transferred embryos * 100. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Sedighe Hoseinimosa
Tehran University of Medical Sciences, Shariati Hospital, Department of Infertility
Outcome results
None listed