The role of omega 3 on the side effect of isotretinoin

Evaluation the role of omega 3 on the side effect of isotretinoin in the acnea vulgaris

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201306238241N2

Enrollment

118

Registered

2013-07-16

Start date

2013-06-15

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acnea vulgaris. Acne vulgaris

Interventions

Intervention 1: cap Omega 3 /BD/for 4 months+20 mg isotretinoin in interventional group. Intervention 2: cap isotretinoin 20 mg daily in control group.

Treatment - Drugs

cap Omega 3 /BD/for 4 months+20 mg isotretinoin in interventional group

cap isotretinoin 20 mg daily in control group

Eligibility

Sex/Gender

All

Age

15 Years to 35 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients with moderate or severe acne (both sexes between the ages of 15 to 35 years old) who do not respond to conventional treatment. Exclusion criteria: patients with hyperlipidemia; hepatitis; lactating pregnant; women not wanting to have long contraception; omega 3 and vitamins A intake; allergy to seafood; aspirin or warfarin use and bleeding disorders .

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Side effect of isotretinoin. Timepoint: In weeks 4, 8, 12 and 16. Method of measurement: Check list.	—

Secondary

Measure	Time frame
Facial erythema. Timepoint: In weeks 4, 8, 12 and 16. Method of measurement: Check list.;Facial dryness. Timepoint: In weeks 4, 8, 12 and 16. Method of measurement: Check list.;Scaling of lip. Timepoint: In weeks 4, 8, 12 and 16. Method of measurement: Check list.;Body skin dryness. Timepoint: In weeks 4, 8, 12 and 16. Method of measurement: Check list.;Cheilitis. Timepoint: In weeks 4, 8, 12 and 16. Method of measurement: Check list.;Crust in nose. Timepoint: In weeks 4, 8, 12 and 16. Method of measurement: Check list.;Epistaxis. Timepoint: In weeks 4, 8, 12 and 16. Method of measurement: Check list.;Eye irritation. Timepoint: In weeks 4, 8, 12 and 16. Method of measurement: Check list.	—

Measure

Time frame

Facial erythema. Timepoint: In weeks 4, 8, 12 and 16. Method of measurement: Check list.;Facial dryness. Timepoint: In weeks 4, 8, 12 and 16. Method of measurement: Check list.;Scaling of lip. Timepoint: In weeks 4, 8, 12 and 16. Method of measurement: Check list.;Body skin dryness. Timepoint: In weeks 4, 8, 12 and 16. Method of measurement: Check list.;Cheilitis. Timepoint: In weeks 4, 8, 12 and 16. Method of measurement: Check list.;Crust in nose. Timepoint: In weeks 4, 8, 12 and 16. Method of measurement: Check list.;Epistaxis. Timepoint: In weeks 4, 8, 12 and 16. Method of measurement: Check list.;Eye irritation. Timepoint: In weeks 4, 8, 12 and 16. Method of measurement: Check list.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mirnezami? Mina

Arak University of Medical Sciences

dr.mirnezami@arakmu.ac.ir+98 86 1224 1411

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 24, 2026