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Comparison of the efficacy of 3 drugs in prevention of side effects of radioiodine therapy in thyroid cancer patients

Comparison of the efficacy of Patoprazole, Metoclopramide, and Ondansetron in management of gastrointestinal symptoms in Thyroid cancer patients treated with I-131

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2013061713705N1
Enrollment
85
Registered
2013-08-11
Start date
2012-04-08
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thyroid carcinoma. Malignant neoplasm of thyroid gland

Interventions

Intervention 1: First group: Metoclopramide, 10 mg, oral, 2 times daily, for 3 days. Intervention 2: second group: Pantoprazole, 20 mg, oral, 2 times daily, for 3 days. Intervention 3: Third group
Ondansetron, 8 mg, oral, 2 times daily, for 3 days. Intervention 4: Forth group: Placebo(Starch Tablet), 8 mg, oral, 2 times daily, for 3 days.
Treatment - Drugs
Placebo
First group: Metoclopramide, 10 mg, oral, 2 times daily, for 3 days
second group: Pantoprazole, 20 mg, oral, 2 times daily, for 3 days
Third group
Ondansetron, 8 mg, oral, 2 times daily, for 3 days
Forth group: Placebo(Starch Tablet), 8 mg, oral, 2 times daily, for 3 days

Sponsors

Vice chancellor for research, Shahid Beheshti University Of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 78 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1- All the patients affected by differentiated thyroid carcinoma. 2- All the patients for whom total thyroidectomy is done. Exclusion criteria: 1- Pregnant women 2- Lactating women

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Nausea. Timepoint: Daily for 3 days. Method of measurement: Check list(Mild, Moderate, and severe).;Vomiting. Timepoint: Daily for 3 days. Method of measurement: check list (has, or has not).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Marjan Mirzababaee

Shahid Beheshti University Of Medical Sciences

m.mirzababaee@yahoo.com+98 21224326609

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Mar 20, 2026