Comparison of analgesic effect - the combination of acetaminophen and ibuprofen in the presence and absence of caffeine on pain after root canal treatment

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201306121760N24

Enrollment

Registered

2013-10-27

Start date

2007-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain of acute apical periodontitis. Acute apical periodontitis of pulpal origin

Interventions

Intervention 1: Group intervention 1: Acetaminophen 325 mg, Ibuprofen 200 mg and caffeine 40 mg [Novafen known named field (the construction company (Brown & burk (uk]

By the Laboratory of Pharmacology, Faculty of Medicine, Babol University of Medical Sciences were divided into three groups of 15. The same drug in capsules (made from gelatin and orange) were placed

Treatment - Drugs

Placebo

Group intervention 1: Acetaminophen 325 mg, Ibuprofen 200 mg and caffeine 40 mg [Novafen known named field (the construction company (Brown & burk (uk]

By the Laboratory of Pharmacology, Faculty of Medicine, Babol University of Medical Sciences were divided into three groups of 15. The same drug in capsules (made from gelatin and orange) were placed

Group intervention 2: Acetaminophen 325 mg, Ibuprofen 200 mg. By the Laboratory of Pharmacology, Faculty of Medicine, Babol University of Medical Sciences were divided into three groups of 15. Th

Group Control: placebo. By the Laboratory of Pharmacology, Faculty of Medicine, Babol University of Medical Sciences were divided into three groups of 15. The same drug in capsules (made from gel

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients with pain origin molars; patients with spontaneous pain (moderate to severe) based on the criterion of a minimum of four (VAS); patients in the age group 65-18 years old. Exclusion criteria: systemic disease; housing consumption in the last 12 hours; history of allergy to NSAIDs and drugs; pregnant and lactating patients.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain after root canal treatment. Timepoint: 4, 6, 12, 24, 48 and 72 hours after intervention. Method of measurement: Visual Analog Scale (VAS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRoghayeh Naeimi Tabiei

Dental College of Babol

naeimi.shabnam@gmail.com+98 11 1229 1408

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026