Effects of antioxidative treatments on pregnancy results

Effects of antioxidative treatments on sperm DNA fragmentation and pregnancy results in IUI

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201306115942N2

Enrollment

150

Registered

2013-08-26

Start date

2013-06-10

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Infertility. Condition 2: Infertility. Condition 3: Infertility. Female infertility associated with male Male infertility Female infertility of cervical origin

Interventions

Intervention 1: one group,vitamin C orally adminstrated daily with 1000 mg dosage for two month. Intervention 2: Control group without any treatment. Intervention 3: one group,zn Supplement orally adm

Treatment - Drugs

one group,vitamin C orally adminstrated daily with 1000 mg dosage for two month.

Control group without any treatment

one group,zn Supplement orally adminstrated daily with 30mg dosage for two month.

one group,vitamin E orally adminstrated daily with 400 mg dosage for two month.

one group,W3 Supplement orally adminstrated daily with1000mg dosage for two month.

Eligibility

Sex/Gender

All

Age

25 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: normal hormonal analysis; infertile women candidates for IUI method; age at least 25 years old and less than 40years old; body mass index minimum 19 kg/m² and less than 30 kg/m²; at least one open fallopian tube in hysterosalpingography; the absence of cervicitis or clinical cervical lesion; SDF (Sperm DNA Fragmentation) less than 30%; the absence of infection in accessory glands; lack of drug addiction and smoking; the absence of varicocele. Exclusion criteria: Irregular menstruation;Galactorrhea; abnormal hysterosalpingography; obstruction in fallopian; adhesion of fallopian; past medical peritoneal surgery; infection in accessory glands

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Sperm DNA fragmentation. Timepoint: Before interposition, 2 month after interposition. Method of measurement: Observation with optic microscope.	—

Secondary

Measure	Time frame
Pregnancy outcomes. Timepoint: Two weeks after IUI. Method of measurement: Pregnancy occurence after positive blood HCG assay.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAliye Ghasemzadeh

Tabriz University of Medical Sciences

gasemzadeha@tbzmed.ac.ir+98 914 340 7313

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026