The amount of helicobacter pylori eradication in renal failure patients

Comparison the effect of different creatinine clearance levels on helicobacter pylori eradication rate in peptic ulcer patients.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013060913609N1

Enrollment

125

Registered

2013-08-18

Start date

2013-01-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

peptic ulcer. gastroduodenal ulcer NOS peptic ulcer NOS

Interventions

Intervention 1: Group 1: Capsule omeprazol 20 milligram (mg) twice daily (OSVEH Pharmaceutical Company)

Tablet clarithromycin 500 mg twice daily (CHEMIDAROU Pharmaceutical Company)

Capsule amoxicillin 1 gram (gr) twice daily (FARABI Pharmaceutical Company) all of them for 2 weeks. Intervention 2: Group 2: Capsule omeprazol 20 milligram (mg) twice daily (OSVEH Pharmaceutical Comp

Capsule amoxicillin 1 gram (gr) twice daily (FARABI Pharmaceutical Company) all of them for 2 weeks. Intervention 3: Group 3: Capsule omeprazol 20 milligram (mg) twice daily (OSVEH Pharmaceutical Comp

Capsule amoxicillin 1 gram (gr) twice daily (FARABI Pharmaceutical Company) all of them for 2 weeks. Intervention 4: Group 4: Capsule omeprazol 20 milligram (mg) twice daily (OSVEH Pharmaceutical Comp

Tablet clarithromycin 250 mg twice daily (CHEMIDAROU Pharmaceutical Company)

Capsule amoxicillin 500 mg twice daily (FARABI Pharmaceutical Company) all of them for 2 weeks. Intervention 5: Group 5: Capsule omeprazol 20 milligram (mg) twice daily (OSVEH Pharmaceutical Company)

Capsule amoxicillin 500 mg twice daily (FARABI Pharmaceutical Company) all of them for 2 weeks.

Treatment - Drugs

Group 1: Capsule omeprazol 20 milligram (mg) twice daily (OSVEH Pharmaceutical Company)

Capsule amoxicillin 1 gram (gr) twice daily (FARABI Pharmaceutical Company) all of them for 2 weeks.

Group 2: Capsule omeprazol 20 milligram (mg) twice daily (OSVEH Pharmaceutical Company)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: Peptic ulcer patients, which have recently been proven by endoscopy and are HP positive, are enrolled. Exclusion criteria: Pregnant women ; patients with cancer ; liver failure; smoking , alcohol consumption ; drug allergy; use of proton pomp inhibitors (PPIs), non steroid anti inflammatory drugs (NSAIDS), bismuth and antibiotics in last 4 weeks.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Helicobacter pylori eradication. Timepoint: Before and 8 weeks after intervention. Method of measurement: Before intervention in antrum sample with rapid urease test and 8 weeks after intervention with urease breath test.	—

Secondary

Measure	Time frame
Creatinine clearance. Timepoint: 3 months before the intervention and at the begining and during the intervention. Method of measurement: According to formula 24 hour urine volume× (urine creatinine/serum creatinine).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi Alimadadi

Golestan University of Medical Sciences

alimadadi1360@yahoo.com+98 17 1442 1653

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026