The effect of intrauterine injection of human chorionic gonadotropin (hCG) before embryo transfer on the implantation and pregnancy rates in the intracytoplasmic sperm injection (ICSI)

Assessment of the effect of intrauterine injection of human chorionic gonadotropin (hCG) before embryo transfer on the implantation and pregnancy rates in the intracytoplasmic sperm injection (ICSI) method among patients who referred to Avicenna Infertility Clinic during 2013-2014.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013060913605N1

Enrollment

121

Registered

2013-08-18

Start date

2013-07-06

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. In vitro fertilization

Interventions

Intervention 1: Intrauterine injection of hCG and embryo transfer in the treatment group: immediately before embryo transfer, 500 IU of hCG dissolved in 40 microliter culture media is instilled into

Treatment - Other

Intrauterine injection of hCG and embryo transfer in the treatment group: immediately before embryo transfer, 500 IU of hCG dissolved in 40 microliter culture media is instilled into the uterine cavi

Intrauterine injection of placebo and embryo transfer in the control group: immediately before embryo transfer only 40 microliter culture media is instilled into the uterine cavity using an inseminati

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: age between 20 and 40 yr; infertility due to male factor, PCO, or with unknown cause; informed consent from couples; obtaining high quality embryos Exclusion criteria: azoospermia or severe oligoasthenoteratospermia; previous successful or failed IVF/ICSI; myometrium or any uterus abnormality; previous myomectomy; moderate to severe endometriosis; hydrosalpynx; obtaining more than 20 ovums or probable OHSS; nonadherence to the study protocol

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Implantation rate. Timepoint: 2 weeks after embryo transfere. Method of measurement: Serum level of B-hCG (mIU/ml) based on laboratory report.;Pregnancy rate. Timepoint: 3 weeks after positive serum B-hCG. Method of measurement: Detection of gestational sac by ultrasonographic exam.	—

Secondary

Measure	Time frame
Serum level of B-hCG. Timepoint: 2 weeks after embryo transfere. Method of measurement: mIU/ml based on laboratory report.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Bita Badehnoosh

Avicenna Infertility Clinic

B.Badehnoosh@avicenna.ac.ir; badehnoosh@dr.com; b_badehnoosh@yahoo.com+98 21 23519

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026