Comparison of isoflurane and sevoflurane in nasal surgeries

Comparison of bleeding during anesthesia with isoflurane and sevoflurane in endoscopic nasal surgeries and tympanomastoidectomy

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201306083289N6

Enrollment

Registered

2014-01-17

Start date

2012-12-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bleeding. Unintentional cut, puncture, perforation or haemorrhage during surgical and medical care( During surgical operation)

Interventions

Intervention 1: Intervention 1: Inhalational Sevoflurane, chemical composition 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)propane, marketed by Abbot Park, North Chicago, Illinois, which is used by 1 MAC,

Treatment - Other

Intervention 1: Inhalational Sevoflurane, chemical composition 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)propane, marketed by Abbot Park, North Chicago, Illinois, which is used by 1 MAC, peri-operative.

Intervention 2: Inhalational Isoflurane, chemical composition 1-chloro-2,2,2-trifluoromethyl ether, marketed by Nicholas Piramal(I)London, which is used by 1 MAC, peri-operative.

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: All the patients who underwent endoscopic sinus surgery or tympanomastoidectomy Exclusion criteria: 1. Age over 55 years 2. Patients with history of cardiovascular problems, hypertension, and COPD 3. Patients under anticoagulation treatment 4. Using tranquilizers 5. Patients with drug abuse

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Bleeding. Timepoint: In the end of surgery. Method of measurement: Quality grading that is recorded in patient's sheet.;Blood pressure. Timepoint: At the beginning of operation and every 15 minutes during surgery. Method of measurement: Measure with mercury sphygmomanometer and record in patient's sheet.;Heart rate. Timepoint: At the beginning of operation and every 15 minutes during surgery. Method of measurement: The number of heart beats per minute is calculated and recorded in the patient's sheet.;Arterial saturation of oxygen. Timepoint: At the beginning of operation and every 15 minutes during surgery. Method of measurement: Measure with pulse oximeter and record in patient's sheet.	—

Measure

Time frame

Bleeding. Timepoint: In the end of surgery. Method of measurement: Quality grading that is recorded in patient's sheet.;Blood pressure. Timepoint: At the beginning of operation and every 15 minutes during surgery. Method of measurement: Measure with mercury sphygmomanometer and record in patient's sheet.;Heart rate. Timepoint: At the beginning of operation and every 15 minutes during surgery. Method of measurement: The number of heart beats per minute is calculated and recorded in the patient's sheet.;Arterial saturation of oxygen. Timepoint: At the beginning of operation and every 15 minutes during surgery. Method of measurement: Measure with pulse oximeter and record in patient's sheet.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Esmaeil Moshiri

Arak University of Medical Sciences

dr_moshiri@arakmu.ac.ir+98 86 1417 3641

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026